Article
A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts.
Journal of cellular physiology - 1 Oct 2014
Aguilar Rodrigo, Grandy Rodrigo, Meza Daniel, Sepulveda Hugo, Pihan Philippe, van Wijnen Andre J, Lian Jane B, Stein Gary S, Stein Janet L, Montecino Martin
Abstract excerpt
The chromatin remodeling complex SWI/SNF and the transcription factor C/EBPβ play critical roles in osteoblastic cells as they jointly control transcription of a number of bone-related target genes. The largest C/EBPβ isoform, LAP*, possesses a short additional N-terminal domain that has been proposed to mediate the interaction of this factor with SWI/SNF in myeloid cells. Here we examine the requirement of a...
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