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Article

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.

Nature cell biology - 24 Jun 2012

Kua Hui-Yi, Liu Huijuan, Leong Wai Fook, Li Lili, Jia Deyong, Ma Gang, Hu Yuanyu, Wang Xueying, Chau Jenny F L, Chen Ye-Guang, Mishina Yuji, Boast Sharon, Yeh James, Xia Li, Chen Guo-Qiang, He Lin, Goff Stephen P, Li Baojie

Abstract excerpt

Defects in stem cell renewal or progenitor cell expansion underlie ageing-related diseases such as osteoporosis. Yet much remains unclear about the mechanisms regulating progenitor expansion. Here we show that the tyrosine kinase c-Abl plays an important role in osteoprogenitor expansion. c-Abl interacts with and phosphorylates BMPRIA and the phosphorylation differentially influences the interaction of BMPRIA...

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Identifiers

PMID: 22729085
DOI: 10.1038/ncb2528
PMCID: PMC8265173

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