Article
c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling
21 Oct 1994
Abstract excerpt
Mice lacking the proto-oncogene c-fos develop the bone disease osteopetrosis. Fos mutant mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was intrinsic to hematopoietic cells. Bone marrow transplantation rescued the osteopetrosis, and ectopic c-fos expression overcame this differentiation block. The lack of Fos also caused a lineage shift between osteoclasts and...
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