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An Lmx1a/b allelic series reveals the role of Lmx1 genes in cochlear nuclei development.

Cell and tissue research - 17 Apr 2026

Iskusnykh Igor Y, Fritzsch Bernd, Yamoah Ebenezer N, Steshina Ekaterina Y, Chizhikov Victor V

Abstract excerpt

Lmx1a/b paralogous genes, which arose from the invertebrate Lmx1b-like gene, are critical for hearing in multiple vertebrate species, and mutations in these genes cause hearing deficits in humans. While the unique and redundant functions of Lmx1a/b in the inner ear are well established, their contribution to the development of the cochlear nuclei, which process and relay auditory information to the brain, is...

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PMID: 41991696
DOI: 10.1007/s00441-026-04064-7
PMCID: PMC13086785

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