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Article

Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status.

Journal of nutritional science and vitaminology - 1 Apr 2009

Crosier Michael D, Peter Inga, Booth Sarah L, Bennett Grace, Dawson-Hughes Bess, Ordovas Jose M

Abstract excerpt

Genetic factors, specifically the VKORC1 and GGCX genes, have been shown to contribute to the interindividual variability in response to the vitamin K-antagonist, warfarin, which influences the dose required to achieve the desired anticoagulation response. These differences in warfarin sensitivity may be explained by differences in vitamin K status. Men and women (n=416, 60-80 y), primarily of European descent,...

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Identifiers

PMID: 19436136
DOI: 10.3177/jnsv.55.112
PMCID: PMC2761647

Genes

VKORC1
GGCX

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