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Article

Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: A pilot study.

Translational research : the journal of laboratory and clinical medicine - 1 Jul 2010

Holzer Gerold, Grasse Anna Verena, Zehetmayer Sonja, Bencur Peter, Bieglmayer Christian, Mannhalter Christine

Abstract excerpt

Susceptibility to osteoporosis seems to be influenced genetically. Previous studies on the effects of genetic polymorphisms on bone mineral density (BMD) showed controversial results. Vitamin K hydrochinon is an important cofactor for gamma carboxylation of osteocalcin. The reduction of vitamin K to vitamin K hydrochinon depends on the vitamin K epoxide reductase complex subunit 1 (VKORC1). We evaluated the...

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Source

Identifiers

PMID: 20621035
DOI: 10.1016/j.trsl.2010.05.005

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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