Article
Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general population.
International journal of hematology - 1 Dec 2006
Kimura Rina, Kokubo Yoshihiro, Miyashita Kotaro, Otsubo Ryoichi, Nagatsuka Kazuyuki, Otsuki Toshiho, Sakata Toshiyuki, Nagura Junko, Okayama Akira, Minematsu Kazuo, Naritomi Hiroaki, Honda Shigenori, Sato Kiyoshi, Tomoike Hitonobu, Miyata Toshiyuki
Abstract excerpt
gamma-Glutamyl carboxylation, a reaction essential for the activity of vitamin K-dependent proteins, requires the concerted actions of gamma-glutamyl carboxylase (GGCX), vitamin K 2, 3-epoxide reductase complex 1 (VKORC1), and the chaperone calumenin (CALU). We evaluated the contribution of genetic polymorphisms in VKORC1, GGCX, and CALU to interindividual variation in the activities of plasma protein C and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.