Article
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Neuro-oncology - 1 Aug 2009
Ichimura Koichi, Pearson Danita M, Kocialkowski Sylvia, Bäcklund L Magnus, Chan Raymond, Jones David T W, Collins V Peter
Abstract excerpt
We screened exon 4 of the gene isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) for mutations in 596 primary intracranial tumors of all major types. Codon 132 mutation was seen in 54% of astrocytomas and 65% of oligodendroglial tumors but in only 6% of glioblastomas (3% of primary and 50% of secondary glioblastomas). There were no mutations in any other type of tumor studied. While mutations in the tumor...
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