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Article

Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review.

Journal of neurosurgery - 1 Jun 2013

Hodges Tiffany R, Choi Bryan D, Bigner Darell D, Yan Hai, Sampson John H

Abstract excerpt

Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered to be frequent and highly conserved in secondary glioblastoma multiforme and lower-grade gliomas. Although IDH1 mutations confer a unique genotype that has been associated with a favorable prognosis, the role of the mutated IDH1 enzyme and its metabolites in tumor initiation and maintenance remains unresolved. However, given that IDH1 mutations are...

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Source

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Identifiers

PMID: 23581583
DOI: 10.3171/2013.3.JNS122282
PMCID: PMC3672384

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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