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Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression

2 May 2019

Abstract excerpt

The capability of cancer cells to manage stress induced by hypoxia, nutrient shortage, acidosis, redox imbalance, loss of calcium homeostasis and exposure to drugs is a key factor to ensure cancer survival and chemoresistance. Among the protective mechanisms utilized by cancer cells to cope with stress a pivotal role is played by the activation of heat shock proteins (HSP) response, anti-oxidant response induced...

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PMID: 31052524
DOI: 10.3390/cancers11050614

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