Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation ofp53downstream genes

1 Jan 1998

Abstract excerpt

The p53 tumor suppressor is the most commonly mutated gene in human cancer. p53 protein is stabilized in response to different checkpoints activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in diverse biological effects, such as cell cycle arrest, apoptosis, senescence, differentiation, and antiangiogenesis. The stable p53 protein is activated by phosphorylation, dephosphorylation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 protein interactions
Share to Cancer-related Molecular Pathways
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10101800
DOI: 10.1006/scbi.1998.0097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation ofp53downstream genesPMID 10101800Read ↗

Cellular adaptation to hypoxia and p53 transcription regulationSemantic proximity Read ↗

Tumor suppressor p53: regulation and functionSemantic proximity Read ↗

The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases.Semantic proximity Read ↗

p53 Isoforms as Cancer Biomarkers and Therapeutic TargetsSemantic proximity Read ↗

Recent Advances in p53Semantic proximity Read ↗

The role of p53-target genes in human cancer.Semantic proximity Read ↗

The P53 pathway: what questions remain to be explored?Semantic proximity Read ↗

The p53 functional circuitSemantic proximity Read ↗

p53 Function and Dysfunction in Human Health and DiseasesSemantic proximity Read ↗

Regulation and function of the p53 tumor suppressor protein.Semantic proximity Read ↗

p53: a guide to apoptosis.Semantic proximity Read ↗

New insights into p53 functions through its target microRNAsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.