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Article

Inclusion of biological knowledge in a Bayesian shrinkage model for joint estimation of SNP effects.

Genetic epidemiology - 1 May 2017

Pereira Miguel, Thompson John R, Weichenberger Christian X, Thomas Duncan C, Minelli Cosetta

Abstract excerpt

With the aim of improving detection of novel single-nucleotide polymorphisms (SNPs) in genetic association studies, we propose a method of including prior biological information in a Bayesian shrinkage model that jointly estimates SNP effects. We assume that the SNP effects follow a normal distribution centered at zero with variance controlled by a shrinkage hyperparameter. We use biological information to define...

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Identifiers

PMID: 28393391
DOI: 10.1002/gepi.22038
PMCID: PMC5397385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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