Detecting rare haplotypes associated with complex diseases using both population and family data: Combined logistic Bayesian Lasso.

Abstract excerpt

Haplotype-based association methods have been developed to understand the genetic architecture of complex diseases. Compared to single-variant-based methods, haplotype methods are thought to be more biologically relevant, since there are typically multiple non-independent genetic variants involved in complex diseases, and the use of haplotypes implicitly accounts for non-independence caused by linkage...

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