Article
Generalized linear modeling with regularization for detecting common disease rare haplotype association.
Genetic epidemiology - 1 May 2009
Guo Wei, Lin Shili
Abstract excerpt
Whole genome association studies (WGAS) have surged in popularity in recent years as technological advances have made large-scale genotyping more feasible and as new exciting results offer tremendous hope and optimism. The logic of WGAS rests upon the common disease/common variant (CD/CV) hypothesis. Detection of association under the common disease/rare variant (CD/RV) scenario is much harder, and the current...
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