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Article

A hybrid bayesian approach for genome-wide association studies on related individuals.

Bioinformatics (Oxford, England) - 15 Dec 2015

Yazdani A, Dunson D B

Abstract excerpt

MOTIVATION: Both single marker and simultaneous analysis face challenges in GWAS due to the large number of markers genotyped for a small number of subjects. This large p small n problem is particularly challenging when the trait under investigation has low heritability. METHOD: In this article, we propose a two-stage approach that is a hybrid method of single and simultaneous analysis designed to improve genomic...

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PMID: 26323717
DOI: 10.1093/bioinformatics/btv496

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