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Article

shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance.

Blood - 12 Mar 2015

Khorashad Jamshid S, Eiring Anna M, Mason Clinton C, Gantz Kevin C, Bowler Amber D, Redwine Hannah M, Yu Fan, Kraft Ira L, Pomicter Anthony D, Reynolds Kimberly R, Iovino Anthony J, Zabriskie Matthew S, Heaton William L, Tantravahi Srinivas K, Kauffman Michael, Shacham Sharon, Chenchik Alex, Bonneau Kyle, Ullman Katharine S, O'Hare Thomas, Deininger Michael W

Abstract excerpt

The mechanisms underlying tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML) patients lacking explanatory BCR-ABL1 kinase domain mutations are incompletely understood. To identify mechanisms of TKI resistance that are independent of BCR-ABL1 kinase activity, we introduced a lentiviral short hairpin RNA (shRNA) library targeting ∼5000 cell signaling genes into K562(R), a CML cell line...

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Source

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Identifiers

PMID: 25573989
DOI: 10.1182/blood-2014-08-588855
PMCID: PMC4357584

Genes

ABL1
BCR
RAN
XPO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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