Article
High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2004
Müller-Tidow Carsten, Schwäble Joachim, Steffen Björn, Tidow Nicola, Brandt Burkhardt, Becker Kerstin, Schulze-Bahr Eric, Halfter Hartmut, Vogt Ulf, Metzger Ralf, Schneider Paul M, Büchner Thomas, Brandts Christian, Berdel Wolfgang E, Serve Hubert
Abstract excerpt
Novel high-throughput analyses in molecular biology allow sensitive and rapid identification of disease-related genes and drug targets. We have used quantitative real-time reverse transcription-PCR reactions (n = 23000) to analyze expression of all human receptor tyrosine kinases (n = 56) in malignant tumors (n = 313) of different origins and normal control samples (n = 58). The different tumor types expressed...
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