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Article

The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation.

The Journal of biological chemistry - 5 May 2006

Row Paula E, Prior Ian A, McCullough John, Clague Michael J, Urbé Sylvie

Abstract excerpt

UBPY is a ubiquitin-specific protease that can deubiquitinate monoubiquitinated receptor tyrosine kinases, as well as process Lys-48- and Lys-63-linked polyubiquitin to lower denomination forms in vitro. Catalytically inactive UBPY localizes to endosomes, which accumulate ubiquitinated proteins. We have explored the sequelae of short interfering RNA-mediated knockdown of UBPY. Global levels of ubiquitinated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16520378
DOI: 10.1074/jbc.M512615200

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STAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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