Article
Haplotype specific-sequencing reveals MBL2 association with asymptomatic Plasmodium falciparum infection.
Malaria journal - 11 May 2009
Boldt Angelica B W, Messias-Reason Iara J, Lell Bertrand, Issifou Saadou, Pedroso Maria Lucia Alves, Kremsner Peter G, Kun Jürgen F J
Abstract excerpt
BACKGROUND: Mannose binding lectin (MBL) has an important role in the activation of the complement system and opsonization of pathogenic microorganisms. Frequent polymorphisms found in the MBL2 gene affect the concentration and functionality of the protein and are associated with enhanced susceptibility to severe malaria in African children. Most MBL2 typing strategies were designed to the analysis of selected...
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