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Article

Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus.

Cancer science - 1 Jul 2009

Baba Seiji, Yamada Yasuhiro, Hatano Yuichiro, Miyazaki Yasuo, Mori Hideki, Shibata Toshiyuki, Hara Akira

Abstract excerpt

Genome-wide DNA hypomethylation and concomitant site-specific gene hypermethylation are among the most common molecular alterations in human neoplasia. Previous studies revealed that genetic reduction of the DNA methylation level results in opposing effects on tumor development, depending on the tumor cell type and on the different stages of the tumorigenesis. For instance, reduced levels of DNA methylation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19432896
DOI: 10.1111/j.1349-7006.2009.01171.x
PMCID: PMC11158800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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