Article
A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells.
Journal of bacteriology - 1 Aug 2008
Bagnoli Fabio, Moschioni Monica, Donati Claudio, Dimitrovska Valentina, Ferlenghi Ilaria, Facciotti Claudia, Muzzi Alessandro, Giusti Fabiola, Emolo Carla, Sinisi Antonella, Hilleringmann Markus, Pansegrau Werner, Censini Stefano, Rappuoli Rino, Covacci Antonello, Masignani Vega, Barocchi Michele A
Abstract excerpt
Analysis of publicly available genomes of Streptococcus pneumoniae has led to the identification of a new genomic element containing genes typical of gram-positive pilus islets (PIs). Here, we demonstrate that this genomic region, herein referred to as PI-2 (consisting of pitA, sipA, pitB, srtG1, and srtG2) codes for a second functional pilus in pneumococcus. Polymerization of the PI-2 pilus requires the backbone...
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