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Article

IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2009

Yu Qianli, Vazquez Randy, Khojeini Elham Vali, Patel Chirag, Venkataramani Raj, Larson Douglas F

Abstract excerpt

Osteopontin (OPN), a key component of the extracellular matrix, is associated with the fibrotic process during tissue remodeling. OPN and the cytokine interleukin (IL)-18 have been shown to be overexpressed in an array of human cardiac pathologies. In the present study, we determined the role of IL-18 in the regulation of cardiac OPN expression and the subsequent interstitial fibrosis and diastolic dysfunction....

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Identifiers

PMID: 19429811
DOI: 10.1152/ajpheart.01285.2008
PMCID: PMC2711747

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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