Article

Transforming Growth Factor β1 Modulates Sex Differences in Cardiac Myofibroblast Activation on Hydrogel Biomaterials

2026-01-20

Abstract excerpt

Cardiac fibrosis is a pathological process in which the myocardium stiffens due to the overproduction of extracellular matrix (ECM) proteins. Cardiac fibroblasts activate to myofibroblasts in response to the inflammatory cytokine transforming growth factor beta1 (TGF-β1) to promote fibrotic scarring. Biological sex also influences cardiac fibrosis progression and patient outcomes, where males exhibit increased fib...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f33c7f53-5023-5c41-aaae-57c0c1d8785c
DOI: 10.64898/2026.01.16.699818

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transforming Growth Factor β1 Modulates Sex Differences in Cardiac Myofibroblast Activation on Hydrogel BiomaterialsDOI 10.64898/2026.01.16.699818Read

Secreted cytokines from inflammatory macrophages modulate sex differences in valvular interstitial cells on hydrogel biomaterialsSemantic proximity Read

The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the HeartSemantic proximity Read

Diverse origins and activation of fibroblasts in cardiac fibrosisSemantic proximity Read

The TGFβ superfamily in cardiac dysfunctionSemantic proximity Read

Computational screen for sex-specific drug effects in a cardiac fibroblast signaling network modelSemantic proximity Read

Cardiac fibroblasts regulate cardiomyocyte hypertrophy through dynamic regulation of type I collagenSemantic proximity Read

Differential Gender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes in Aging Mice.Semantic proximity Read

Cardiomyocyte-expressed TGFβ signals to fibroblasts to program early heart maturation and adult myocyte identitySemantic proximity Read

Fibrotic extracellular matrix impacts cardiomyocyte phenotype and function in an iPSC-derived isogenic model of cardiac fibrosis.Semantic proximity Read

Featured Article: TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblastsSemantic proximity Read

TGF-β induces a heart failure phenotype via fibroblasts exosome signalingSemantic proximity Read

Properties and Immune Function of Cardiac Fibroblasts.Semantic proximity Read