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Article

Osteopontin RNA aptamer can prevent and reverse pressure overload-induced heart failure.

Cardiovascular research - 1 May 2017

Li Jihe, Yousefi Keyvan, Ding Wen, Singh Jayanti, Shehadeh Lina A

Abstract excerpt

AIMS: Cardiac myocyte hypertrophy, the main compensatory response to chronic stress in the heart often progresses to a state of decompensation that can lead to heart failure. Osteopontin (OPN) is an effector for extracellular signalling that induces myocyte growth and fibrosis. Although increased OPN activity has been observed in stressed myocytes and fibroblasts, the detailed and long term effects of blocking...

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Share to Aptamers, Nucleotide
Share to Arterial Pressure
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinase

Share to Ventricular Dysfunction, Left

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Source

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Identifiers

PMID: 28453726
DOI: 10.1093/cvr/cvx016
PMCID: PMC7526752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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