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Article

Interleukin-18, rheumatoid arthritis, and tissue destruction

15 Nov 1999

Abstract excerpt

In this issue of the JCI, J. Alastair Gracie et al. highlight the central importance of IL-18 among several novel cytokines that participate in erosive, inflammatory arthritis (1). The authors base their arguments on experimental results obtained in vitro with human synovial tissue and in vivo with mice immunized with collagen in the presence of incomplete Freund’s adjuvant. IL-18 and its receptors. The...

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PMID: 10562294
DOI: 10.1172/jci8731

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