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Article

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

8 May 2009

Abstract excerpt

Nuclear factor TDP-43 has been reported to play multiple roles in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. From a structural point of view, TDP-43 is a member of the hnRNP protein family whose structure includes two RRM domains flanked by the N-terminus and C-terminal regions. Like many members of this family, the C-terminal region can interact with cellular factors and thus serve to...

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PMID: 19429692
DOI: 10.1093/nar/gkp342

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