Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TDP-43 regulatesβ-adducin(Add2) transcript stability

3 Oct 2014

Abstract excerpt

TDP-43 is an RNA-binding protein involved in several steps of mRNA metabolism including transcription, splicing and stability. It is also involved in ALS and FTD, neurodegenerative diseases characterized by TDP-43 nuclear depletion. We previously identified TDP-43 as a binder of the downstream element (DSE) of the β-Adducin (Add2) brain-specific polyadenylation site (A4 PAS), suggesting its involvement in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25602706
DOI: 10.1080/15476286.2014.996081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TDP-43 regulatesβ-adducin(Add2) transcript stabilityPMID 25602706Read ↗

Decoding TDP-43: the molecular chameleon of neurodegenerative diseasesSemantic proximity Read ↗

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulationSemantic proximity Read ↗

Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and diseaseSemantic proximity Read ↗

Familial ALS/FTD-associated RNA-binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation in vitroSemantic proximity Read ↗

Familial ALS/FTD-associated RNA-Binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation <i>in vitro</i>Semantic proximity Read ↗

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes.Semantic proximity Read ↗

Characterization of the distal polyadenylation site of the ß-adducin (Add2) pre-mRNA.Semantic proximity Read ↗

Connecting TDP-43 Pathology with Neuropathy.Semantic proximity Read ↗

The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative MechanismSemantic proximity Read ↗

TDP-43 Epigenetic Facets and Their Neurodegenerative ImplicationsSemantic proximity Read ↗

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivoSemantic proximity Read ↗

TDP-43 loss of function drives aberrant splicing in Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.