Article
Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence.
Neuroscience letters - 5 Apr 2010
Lohoff Falk W, Bloch Paul J, Hodge Rachel, Nall Aleksandra H, Ferraro Thomas N, Kampman Kyle M, Dackis Charles A, O'Brien Charles P, Pettinati Helen M, Oslin David W
Abstract excerpt
Genetic research on cocaine dependence (CD) may help clarify our understanding of the disorder as well as provide novel insights for effective treatment. Since dopamine neurotransmission has been shown to be involved in drug reward, related genes are plausible candidates for susceptibility to CD. The dopamine receptor D(2) (DRD2) protein and dopamine transporter (DAT1) protein play regulatory roles in dopamine...
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