Article
Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence.
Neuroscience letters - 8 Aug 2008
Lohoff Falk W, Bloch Paul J, Weller Andrew E, Nall Aleksandra H, Doyle Glenn A, Buono Russell J, Ferraro Thomas N, Kampman Kyle M, Pettinati Helen M, Dackis Charles A, Oslin David W, O'Brien Charles P, Berrettini Wade H
Abstract excerpt
Dopaminergic brain systems have been implicated to play a major role in drug reward, thus making genes involved in these circuits plausible candidates for susceptibility to substance use disorders. The cocaine- and amphetamine-regulated transcript peptide (CARTPT) is involved in reward and feeding behavior and has functional characteristics of an endogenous psychostimulant. In this study we tested the hypothesis...
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