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Article

Construction and characterization of a new hepatitis C virus genotype 6a subgenomic replicon that is prone to render the sofosbuvir resistance.

Journal of medical virology - 1 Sept 2023

Liu Chaolun, Guo Mingzhe, Han Lin, Lu Jie, Xiang Xiaogang, Xie Qing, Nouhin Janin, Duong Veasna, Tong Yimin, Zhong Jin

Abstract excerpt

Hepatitis C virus (HCV) infection remains a challenge to human public health despite the development of highly effective direct-acting antivirals (DAAs). Sofosbuvir (SOF), a key component in most DAA-based anti-HCV cocktail regimens, is a potent viral RNA polymerase (NS5B) inhibitor with a high barrier to drug resistance. The serine-to-threonine mutation at NS5B 282 (S282T) confers the SOF resistance, but...

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PMID: 37721366
DOI: 10.1002/jmv.29103

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