Article
Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms.
PloS one - 1 Jan 2011
Hunt Piper R, Son Tae Gen, Wilson Mark A, Yu Quian-Sheng, Wood William H, Zhang Yongqing, Becker Kevin G, Greig Nigel H, Mattson Mark P, Camandola Simonetta, Wolkow Catherine A
Abstract excerpt
Hormesis occurs when a low level stress elicits adaptive beneficial responses that protect against subsequent exposure to severe stress. Recent findings suggest that mild oxidative and thermal stress can extend lifespan by hormetic mechanisms. Here we show that the botanical pesticide plumbagin, while toxic to C. elegans nematodes at high doses, extends lifespan at low doses. Because plumbagin is a naphthoquinone...
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