Article

Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity

2020-07-25

Abstract excerpt

Transcriptome-based drug screening is emerging as a powerful tool to identify geroprotective compounds to intervene in age-related disease. We hypothesized that, by mimicking the transcriptional signature of the highly conserved longevity intervention of FOXO3 ( daf-16 in worms) overexpression, we could identify and repurpose compounds with similar downstream effects to increase longevity. Our in silico screen,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b3ef5447-5ca6-5378-bc01-25d6a2935189
DOI: 10.1101/2020.07.24.219584

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevityDOI 10.1101/2020.07.24.219584Read

Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse <i>Caenorhabditis</i> nematodesSemantic proximity Read

Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans.Semantic proximity Read

DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegansSemantic proximity Read

Low-dose Naltrexone (LDN) extends healthspan and lifespan through activation of the transcription factor SKN-1/NRF2 in C. elegans.Semantic proximity Read

The Nuclear RNAi Pathway Regulates DAF-16/FOXO to Control <i>C. elegans</i> Longevity and <i>Dauer</i> EntrySemantic proximity Read

Six drivers of aging identified among genes differentially expressed with ageSemantic proximity Read

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathwaySemantic proximity Read

Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression.Semantic proximity Read

Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way.Semantic proximity Read

Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegansSemantic proximity Read

Drug repurposing for ageing research using model organismsSemantic proximity Read

Drug repurposing for aging research using model organismsSemantic proximity Read