Article
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.
Cancer cell - 1 May 2008
Petrova Tatiana V, Nykänen Antti, Norrmén Camilla, Ivanov Konstantin I, Andersson Leif C, Haglund Caj, Puolakkainen Pauli, Wempe Frank, von Melchner Harald, Gradwohl Gérard, Vanharanta Sakari, Aaltonen Lauri A, Saharinen Juha, Gentile Massimiliano, Clarke Alan, Taipale Jussi, Oliver Guillermo, Alitalo Kari
Abstract excerpt
The Drosophila transcription factor Prospero functions as a tumor suppressor, and it has been suggested that the human counterpart of Prospero, PROX1, acts similarly in human cancers. However, we show here that PROX1 promotes dysplasia in colonic adenomas and colorectal cancer progression. PROX1 expression marks the transition from benign colon adenoma to carcinoma in situ, and its loss inhibits growth of human...
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