Article
Genetic variants in GREM2 are associated with bone mineral density in a southern Chinese population.
The Journal of clinical endocrinology and metabolism - 1 Sept 2013
Cheung Ching-Lung, Lau Kam-Shing, Sham Pak-Chung, Tan Kathryn C B, Kung Annie W C
Abstract excerpt
CONTEXT: Gremlin 2 (GREM2) is a regulator of osteoblast differentiation and osteogenesis. A recent genome-wide association study identified GREM2 as a novel susceptibility gene for trabecular volumetric bone mineral density (BMD). OBJECTIVE: We investigated whether GREM2 gene variants were associated with areal BMD in southern Chinese people. RESEARCH DESIGN AND METHODS: We genotyped 108 single-nucleotide...
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