Article
The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation.
Frontiers in endocrinology - 1 Jan 2021
Tsai Dung-Jang, Fang Wen-Hui, Wu Li-Wei, Tai Ming-Cheng, Kao Chung-Cheng, Huang Shih-Ming, Chen Wei-Teing, Hsiao Po-Jen, Chiu Chih-Chien, Su Wen, Wu Chia-Chun, Su Sui-Lung
Abstract excerpt
Purpose: Genome-wide association studies have identified numerous genetic variants that are associated with osteoporosis risk; however, most of them are present in the non-coding regions of the genome and the functional mechanisms are unknown. In this study, we aimed to investigate the potential variation in runt domain transcription factor 2 (RUNX2), which is an osteoblast-specific transcription factor that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.