Article
Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes.
PLoS genetics - 1 May 2009
Zhao Yongzhong, Marotta Michael, Eichler Evan E, Eng Charis, Tanaka Hisashi
Abstract excerpt
Copy number variations (CNVs) represent a large source of genetic variation in humans and have been increasingly studied for disease association. A deletion polymorphism of the gene encoding the cytosolic detoxification enzyme glutathione S-transferase theta 1 (GSTT1) has been extensively studied for cancer susceptibility (919 studies, from HuGE navigator, http://www.HuGEnavigator.net/). However, clear...
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