Article
Population-specific GSTM1 copy number variation.
Human molecular genetics - 15 Jan 2009
Huang R Stephanie, Chen Peixian, Wisel Steve, Duan Shiwei, Zhang Wei, Cook Edwin H, Das Soma, Cox Nancy J, Dolan M Eileen
Abstract excerpt
As one of the major glutathione conjugation enzymes, GSTM1 detoxifies a number of drugs and xenobiotics. Its expression and activity have been shown to correlate both with cancer risks and drug resistance. Through a genome-wide association study, we identified a significant association between Ha...
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