Article
Explorative genetic association study of GSTT2B copy number variant in complex disease risks.
Annals of human biology - 1 May 2016
Iorio Andrea, Polimanti Renato, Calandro Melania, Graziano Maria Eleonora, Piacentini Sara, Bucossi Serena, Squitti Rosanna, Lazzarin Natalia, Scano Giuseppina, Limbruno Giancarlo Maria, Manfellotto Dario, Fuciarelli Maria
Abstract excerpt
BACKGROUND: Glutathione S-transferases (GSTs) are the main phase II enzymes involved in cellular detoxification. Through phase I and phase II detoxification reactions, the cell is able to detoxify endogenous and exogenous toxic compounds. AIMS: This study focused attention on the GSTT2B copy number variant (CNV) in order to explore its involvement in the genetic pre-disposition to asthma, Alzheimer's disease...
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