Article
Rapid triplex asymmetric real-time PCR hybridization probe assay for the joint genotyping of F2, F5 and F12.
Clinical biochemistry - 1 Aug 2009
Martínez-Serra J, Gutierrez A, Amat J C, Galmés B, Vila A, Julia M, López H, Bautista A M, Truyols C, Ros T, Navarro M, Canaro M, Díaz M, Besalduch J
Abstract excerpt
INTRODUCTION: The Factor 5 Leiden mutation and the G20210A variant of Factor 2 are two important risk factors for hereditary thromboembolism. Several reports have demonstrated that homozygous carriers for C46T mutation of the Factor 12 gene is associated with a significant increased risk for the development of coronary disease as well as cerebral and peripheral venous thrombosis. DESIGN AND METHODS: We develop a...
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