Article
Combined factor V leiden (G1691A) and prothrombin (G20210A) genotyping by multiplex real-time polymerase chain reaction using fluorescent resonance energy transfer hybridization probes on the Rotor-Gene 2000.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jun 2003
Ameziane Nejma, Lamotte Maryse, Lamoril Jérôme, Lebret Dominique, Deybach Jean-Charles, Kaiser Thomas, de Prost Dominique
Abstract excerpt
Several methods have been developed to detect common single point mutations in the factor V and prothrobin genes that are risk factors for thrombophilia. Most are based on PCR followed by restriction enzyme digestion and electrophoresis (RFLP), but gel analysis has certain limitations, and alternative detection methods, including real-time PCR, have therefore been developed. In this study we developed and...
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