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Article

FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors.

PloS one - 1 Jan 2014

Jardim Denis L, Wheler Jennifer J, Hess Kenneth, Tsimberidou Apostolia M, Zinner Ralph, Janku Filip, Subbiah Vivek, Naing Aung, Piha-Paul Sarina A, Westin Shannon N, Roy-Chowdhuri Sinchita, Meric-Bernstam Funda, Hong David S

Abstract excerpt

PURPOSE: FBXW7 is a tumor suppressor gene responsible for the degradation of several proto-oncogenes. Preclinical data suggest that FBXW7 mutations sensitize cells to mTOR inhibitors. Clinicopathologic characteristics of cancer patients with FBXW7 mutations and their responses to mTOR inhibitors remain unknown. METHODS: Using multiplex gene panels we evaluated how the FBXW7 mutation affected the cancer phenotype...

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Identifiers

PMID: 24586741
DOI: 10.1371/journal.pone.0089388
PMCID: PMC3929689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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