Article
The tumor suppressor gene FBXW7 is disrupted by a constitutional t(3;4)(q21;q31) in a patient with renal cell cancer.
Cancer genetics and cytogenetics - 1 Dec 2009
Kuiper Roland P, Vreede Lilian, Venkatachalam Ramprasath, Ricketts Chris, Kamping Eveline, Verwiel Eugene, Govaerts Lutgarde, Debiec-Rychter Maria, Lerut Evelyne, van Erp Femke, Hoogerbrugge Nicoline, van Kempen Lianne, Schoenmakers Eric F P M, Bonne Anita, Maher Eamonn R, Geurts van Kessel Ad
Abstract excerpt
FBXW7 (alias CDC4) is a p53-dependent tumor suppressor gene that exhibits mutations or deletions in a variety of human tumors. Mutation or deletion of the FBXW7 gene has been associated with an increase in chromosomal instability and cell cycle progression. In addition, the FBXW7 protein has been found to act as a component of the ubiquitin proteasome system and to degrade several oncogenic proteins that function...
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