Article
hCDC4 variation in osteosarcoma.
Cancer genetics and cytogenetics - 1 Sept 2006
Yan Taiqiang, Wunder Jay S, Gokgoz Nalan, Seto Kelly K Y, Bell Robert S, Andrulis Irene L
Abstract excerpt
The hCDC4 gene (also known as Fbw7 or Archipelago) encodes an F-box protein that is responsible for targeting cyclin E for Skp1-cullin-F box protein (SCF) ubiquitination and proteosomal degradation. Disruption of this pathway has been associated with chromosomal instability and aneuploidy in several cancer cell lines and primary tumors. This study aimed to examine whether hCDC4 mutations contribute to aneuploidy...
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