Article
Mutational analysis of the hCDC4 gene in gastric carcinomas.
European journal of cancer (Oxford, England : 1990) - 1 Sept 2006
Lee J W, Soung Y H, Kim H J, Park W S, Nam S W, Kim S H, Lee J Y, Yoo N J, Lee S H
Abstract excerpt
hCDC4, a ubiquitin ligase, plays a role in the control of cell cycle and chromosome stability. The hCDC4 gene is considered a tumour suppressor gene and is mutated in several human neoplasias, including colorectal and endometrial tumours. Data on the hCDC4 mutation in gastric cancer is, however, lacking. This study explored the possibility that hCDC4 mutation is involved in the development of gastric cancer. The...
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