Article
Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patients.
Dementia and geriatric cognitive disorders - 1 Jan 2006
Huey Edward D, Mirza Nadeem, Putnam Karen T, Soares Holly, Csako Gyorgy, Levy James A, Copenhaver Brittany, Cohen Robert M, Sunderland Trey
Abstract excerpt
BACKGROUND: Cerebrospinal fluid (CSF) measures of beta-amyloid(1-42 )and tau differ between patients with Alzheimer's Disease (AD) and elderly normal controls. The effect of time and APOE genotype on these biomarkers continues to be elucidated. METHODS: We assessed CSF beta-amyloid(1-42) and tau in 20 mild-to-moderate AD patients, 11 APOE epsilon4+ and 9 APOE epsilon4-, over a mean time of 3.8 years (range 1-11.1...
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