Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ApoE alleles and tau markers in patients with different levels of cognitive impairment.

Archives of medical research - 1 Jan 2000

Lavados Manuel, Farías Gustavo, Rothhammer Francisco, Guillon Marta, Mujica Maria C, Maccioni Cristóbal, Maccioni Ricardo B

Abstract excerpt

BACKGROUND: The presence of brain hyperphosphorylated tau constitutes a hallmark of neurodegenerative disorders of the Alzheimer's type. This report describes the relationships between tau markers in the cerebrospinal fluid (CSF), the degree of cognitive impairment and the predictive value of genetic markers such the alleles of apolipoprotein E, namely, the presence of Apo-epsilon4, as part of a longitudinal...

Topics

Aged
Alleles
Apolipoproteins E
Cognition Disorders
Female
Genetic Markers
Genotype
Humans
Longitudinal Studies
Male
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Isoforms

tau Proteins

Source

Identifiers

PMID: 16099324
DOI: 10.1016/j.arcmed.2005.03.036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16099324-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ApoE alleles and tau markers in patients with different levels of cognitive impairment.PMID 16099324Read ↗

Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.Semantic proximity Read ↗

Apolipoprotein E epsilon 4 allele in association with global cognitive performance and CSF markers in Alzheimer's disease.Semantic proximity Read ↗

CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI.Semantic proximity Read ↗

CSF biomarkers in Alzheimer's disease and controls: associations with APOE genotype are modified by age.Semantic proximity Read ↗

Prevalence of ApoE Alleles in a Spanish Population of Patients with a Clinical Diagnosis of Alzheimer's Disease: An Observational Case-Control Study.Semantic proximity Read ↗

Apolipoprotein E polymorphism in elderly Chilean people with Alzheimer's disease.Semantic proximity Read ↗

Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele.Semantic proximity Read ↗

[Dementia and cognitive impairment pattern: its association with epsilon4 allele of apolipoprotein E gene].Semantic proximity Read ↗

Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment.Semantic proximity Read ↗

The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease.Semantic proximity Read ↗

Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex.Semantic proximity Read ↗

Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.