Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair

6 May 2009

Abstract excerpt

Mismatch repair contributes to genetic stability, and inactivation of the mammalian pathway leads to tumor development. Mismatch correction occurs by an excision-repair mechanism and has been shown to depend on the 5' to 3' hydrolytic activity exonuclease 1 (Exo1) in eukaryotic cells. However, genetic and biochemical studies have indicated that one or more Exo1-independent modes of mismatch repair also exist. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19420220
DOI: 10.1073/pnas.0903654106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A possible mechanism for exonuclease 1-independent eukaryotic mismatch repairPMID 19420220Read ↗

Exonuclease 1-dependent and independent mismatch repair.Semantic proximity Read ↗

Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in CancerSemantic proximity Read ↗

DNA mismatch repair and its many roles in eukaryotic cells.Semantic proximity Read ↗

Exonuclease 1 and its versatile roles in DNA repair.Semantic proximity Read ↗

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility.Semantic proximity Read ↗

Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair.Semantic proximity Read ↗

Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.Semantic proximity Read ↗

Endonucleolytic Function of MutLα in Human Mismatch RepairSemantic proximity Read ↗

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in <i> Exo1 <sup>D173A</sup> </i> miceSemantic proximity Read ↗

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Semantic proximity Read ↗

Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.