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Article

Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro.

Endocrinology - 1 Sept 2005

Gazzerro Elisabetta, Deregowski Valerie, Vaira Sergio, Canalis Ernesto

Abstract excerpt

Twisted gastrulation (Tsg) is a secreted glycoprotein that binds bone morphogenetic protein-2 (BMP-2) and BMP-4 and can display both BMP agonist and antagonist functions. Tsg acts as a BMP agonist in chondrocytes, but its expression and actions on the differentiation of cells of the osteoblastic lineage are not known. We investigated the effects of Tsg overexpression by transducing murine ST-2 stromal and MC3T3...

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Source

Identifiers

PMID: 15919755
DOI: 10.1210/en.2005-0053

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro.PMID 15919755Read ↗

Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function.Semantic proximity Read ↗

Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signaling.Semantic proximity Read ↗

Molecular mechanism of BMP signal control by Twisted gastrulation.Semantic proximity Read ↗

Mammalian twisted gastrulation is essential for skeleto-lymphogenesis.Semantic proximity Read ↗

Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain developmentSemantic proximity Read ↗

Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis.Semantic proximity Read ↗

The pro-BMP activity of Twisted gastrulation is independent of BMP binding.Semantic proximity Read ↗

BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalizationSemantic proximity Read ↗

Identification of a second Xenopus twisted gastrulation gene.Semantic proximity Read ↗

BMP‐5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte culturesSemantic proximity Read ↗

Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning.Semantic proximity Read ↗

Combinatorial signaling by Twisted Gastrulation and Decapentaplegic.Semantic proximity Read ↗

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