Article
Nucleotide promiscuity of 3-phosphoglycerate kinase is in focus: implications for the design of better anti-HIV analogues.
Molecular bioSystems - 1 Jun 2011
Varga Andrea, Chaloin Laurent, Sági Gyula, Sendula Róbert, Gráczer Eva, Liliom Károly, Závodszky Péter, Lionne Corinne, Vas Mária
Abstract excerpt
The wide specificity of 3-phosphoglycerate kinase (PGK) towards its nucleotide substrate is a property that allows contribution of this enzyme to the effective phosphorylation (i.e. activation) of nucleotide-based pro-drugs against HIV. Here, the structural basis of the nucleotide-PGK interaction is characterised in comparison to other kinases, namely pyruvate kinase (PK) and creatine kinase (CK), by enzyme...
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