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Article

Mechanistic insight into the functional transition of the enzyme guanylate kinase induced by a single mutation.

Scientific reports - 12 Feb 2015

Zhang Yuebin, Niu Huiyan, Li Yan, Chu Huiying, Shen Hujun, Zhang Dinglin, Li Guohui

Abstract excerpt

Dramatic functional changes of enzyme usually require scores of alterations in amino acid sequence. However, in the case of guanylate kinase (GK), the functional novelty is induced by a single (S→P) mutation, leading to the functional transition of the enzyme from a phosphoryl transfer kinase into a phosphorprotein interaction domain. Here, by using molecular dynamic (MD) and metadynamics simulations, we provide...

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Identifiers

PMID: 25672880
DOI: 10.1038/srep08405
PMCID: PMC4325336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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